Based on Sony Pictures Entertainment's Columbia Pictures' upcoming feature film, Spider-Man 3 allows players to experience the actions of heroic red-suited Spider-Man and, for the first time ever, his darker, more mysterious black-suited persona. Set in a larger, dynamic, free-roaming New York City, the game gives players the freedom to choose their own gameplay experience through multiple movie-based and original storylines, fully integrated city missions and performance rewards including improved speed, combat maneuvers and agility.

In Spider-Man 3, players draw upon Spider-Man's completely revamped combat abilities as they protect the city and defeat nemeses using expanded aerial fighting, finishing moves and dynamic webbing during missions and epic boss battles never seen before in game.