The player (Solid Snake) must navigate the game world in order to progress, using stealth and cunning in addition to traditional combat. It will utilize the series' traditional third person view with full camera manipulation, but also allows the freedom to play in first-person mode, as well as an over the shoulder view which can be switched from right shoulder to left for easy corner maneuvering.

The Close Quarters Combat system will also be completely revamped. The player will also be able to interrogate guards for information and supplies just like in real life.

Several elements from previous titles return in modified forms. Players will also utilize a new form of camouflage called "Octocamo", which replaces the camouflage system featured in Metal Gear Solid 3 and the Optical Camouflage seen in MGS1 and MGS2.

Blue when disabled, the Octocamo suit allows the wearer to blend in with any surface within a few seconds. A new monocular device called "Solid Eye" replaces the various binoculars and image intensifiers from previous titles, and a steel drum compliments the series' traditional cardboard box disguise. It is able to deflect bullets, and can be rolled to knock enemy soldiers over.