The videogame is set on Pandora, an alien planet that is also the main movie attraction. The game includes the Na'vi, Pandora's indigenous people and discover other life forms.

On July 24 2007, it was announced that Ubisoft would be developing Avatar: The Game in conjunction with director James Cameron as he films Avatar.

On July 24 2009, Ubisoft announced that Sigourney Weaver will reprise her role from the film and voice Dr. Grace Augustine. Other actors from the film that will appear in the game include Michelle Rodriguez, Giovanni Ribisi and Stephen Lang. Michelle Rodriguez's character, Trudy Chacon, functions as the player's chopper pilot throughout the Xbox 360, Playstation 3 system and PC versions of the game.

Ribisi reprises his role as the arrogant Parker Selfridge, appearing exclusively in the Wii version of the game. The film's antagonist, Col. Quaritch, played and voiced by Lang, will appear in the Xbox 360, Playstation 3 system and PC versions.