The PC game Desperate Housewives is a lifestyle simulation PC game based on the ABC-TV series, produced by Touchstone Television.. Developed by Liquid Entertainment, Desperate Housewives is scheduled to hit retail shelves this fall.

In the Desperate Housewives game, players take on the role of a new housewife who moves into Wisteria Lane and unlocks the delicious scandals hidden in the seemingly "perfect" neighborhood. Mary Alice Young (voiced by Brenda Strong in the game) serves as the omniscient narrator in this lifestyle simulation game.